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Clinical characteristics and outcomes of biopsy-proven diabetic nephropathy
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 386-392 doi: 10.1007/s11684-017-0574-z
Kidney damage is common in patients with diabetes mellitus (DM). However, whether the type of kidney damage can be reliably diagnosed using clinical data alone remains unclear. Predictive factors for diabetic nephropathy (DN) outcomes are also poorly understood. In this study, the clinical manifestations of 111 cases of biopsy-proven DN were described, and the clinical and pathological parameters of patients with different DN outcomes were compared. Results showed that long DM duration (>10 years in 32.4% of patients), severe proteinuria (62.2%), and renal dysfunction (estimated glomerular filtration rate [eGFR]<60 mL/(min·1.73 m2)) (52.3%) did not accurately indicate whether the condition of these patients progressed to DN. Hematuria (48.6%) failed to specify either DN or nondiabetic renal disease. Diabetic retinopathy (78.4%) was a crucial complication in patients with DN. Kaplan–Meier analysis revealed that the renal survival of 53 patients who were diagnosed with DN and were followed up was not significantly associated with glomerular classification (P>0.05). Cox’s regression analysis demonstrated that renal survival time was significantly influenced by sex (b= 1.394, P= 0.038), hematuria (b= 0.036, P= 0.029), and eGFR (b= −0.039, P= 0.002) but was not significantly affected by age, 24 h urinary protein excretion, or glomerular classification (P>0.05). In conclusion, the clinical characteristics of DN vary, and renal biopsy is necessary to determine renal damage patterns. Sex, hematuria, and the eGFR may affect DN outcomes, whereas the glomerular classification may not.
关键词: diabetic nephropathy clinical characteristics renal biopsy outcomes
Design and evaluation of a novel biopsy needle with hemostatic function
《机械工程前沿(英文)》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0738-7
关键词: cancer diagnosis biopsy needle hemostatic function predictive model coupled Eulerian−Lagrangian
Application of liquid biopsy in precision medicine: opportunities and challenges
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《医学前沿(英文)》 2017年 第11卷 第4期 页码 522-527 doi: 10.1007/s11684-017-0526-7
Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosis and treatment of individuals. Detecting circulating tumor cell (CTC) or circulating tumor DNA (ctDNA) in plasma or serum could serve as liquid biopsy, which would be useful for numerous diagnostic applications. Liquid biopsies can help clinicians screen and detect cancer early, stratify patients to the most suitable treatment and real-time monitoring of treatment response and resistance mechanisms in the tumor, evaluate the risk for metastatic relapse, and estimate prognosis. We summarized the advantages and disadvantages of tissue and liquid biopsies. We also further compared and analyzed the advantages and limitations of detecting CTCs, ctDNAs, and exosomes. Furthermore, we reviewed the literature related with the application of serum or plasma CTCs, ctDNAs, and exosomes for diagnosis and prognosis of cancer. We also analyzed their opportunities and challenges as future biomarkers. In the future, liquid biopsies could be used to guide cancer treatment. They could also provide the ideal scheme to personalize treatment in precision medicine.
关键词: liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine
Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 395-405 doi: 10.1007/s11684-012-0231-5
Pulmonary lymphangioleiomyomatosis (LAM) is a rare cystic lung disease that targets women during their reproductive years. A confident diagnosis can often be based on clinical grounds, but diagnostic certainty requires pathological analysis. Although surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuse lung disease, it is also associated with higher morbidity and mortality than alternative, less invasive techniques. The objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of LAM. We conducted two online surveys of over 1 000 LAM patients registered with the LAM Foundation who were accessible by email. Transbronchial biopsy specimens were subsequently collected and reviewed by an expert pathologist to validate the diagnosis. We found that transbronchial biopsy has a yield of approximately 60% in patients with LAM. We conclude that transbronchial biopsy may be a safe and effective method for establishing the diagnosis of LAM, obviating the need for surgical lung biopsy in more than half of LAM patients.
关键词: lymphangioleiomyomatosis lymphangiomyomatosis multicystic lung disease diffuse cystic lung disease transbronchial biopsy perivascular epithelioid cell tumor (PEComa) HMB-45
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 329-331 doi: 10.1007/s11684-012-0211-9
Ischemic postconditioning was defined as rapid intermittent interruptions of blood ?ow in the early phase of reperfusion, which has been found to be protective against renal ischemia-reperfusion injury (IRI) in animal models but not in clinical trials. We describe a case that the allograft renal vein was twisted because of the surgeon’s mistake, which caused the warm ischemia of allograft after reperfusion. The allograft restored blood flow without second reperfusion and cold preservation after 9 min of warm ischemia. The patient was followed up for 3 months and the allograft worked well without complications.
关键词: renal transplantation vein twist ischemia-reperfusion injury
Giant renal angiomyolipoma with tuberous sclerosis complex
Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 495-498 doi: 10.1007/s11684-009-0068-8
关键词: renal angiomyolipoma tuberous sclerosis complex hemorrhage
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2
《医学前沿(英文)》 2023年 第17卷 第3期 页码 503-517 doi: 10.1007/s11684-022-0947-9
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
《医学前沿(英文)》 2019年 第13卷 第2期 页码 267-276 doi: 10.1007/s11684-017-0586-8
关键词: Shenkang injection senescence renal tubular epithelial cells diabetic nephropathy
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
《医学前沿(英文)》 2007年 第1卷 第3期 页码 308-311 doi: 10.1007/s11684-007-0059-6
Effect of pirfenidone on renal tubulointerstitial fibrosis
Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 316-322 doi: 10.1007/s11684-009-0045-2
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
《医学前沿(英文)》 2008年 第2卷 第1期 页码 25-34 doi: 10.1007/s11684-008-0006-1
Minggen YANG, Xiaokun ZHAO
《医学前沿(英文)》 2009年 第3卷 第2期 页码 191-196 doi: 10.1007/s11684-009-0026-5
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
《医学前沿(英文)》 2007年 第1卷 第2期 页码 167-172 doi: 10.1007/s11684-007-0031-5
《医学前沿(英文)》 doi: 10.1007/s11684-023-1029-3
关键词: tumor prognosis molecular Microbiome subsets determine center analysis microbiome transcriptome data
Application progress of lymphography in oncology
Yang YU, Jibin LIU, Lixue YIN
《医学前沿(英文)》 2009年 第3卷 第1期 页码 13-19 doi: 10.1007/s11684-009-0016-7
关键词: lymphography lymphatic metastasis sentinel lymph node biopsy
标题 作者 时间 类型 操作
The second short-term warm ischemia after vascular anastomosis did not affect early renal function recoveryin renal transplantation: a case report
null
期刊论文
Giant renal angiomyolipoma with tuberous sclerosis complex
Ouyan SHI PhD, Guodong XU BM, Chunxiang WANG BM,
期刊论文
Preventive effect of Shenkang injection against high glucose-induced senescence of renal tubular cells
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
期刊论文
Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney
YU Xiaofang, XU Xialian, YE Zhibin
期刊论文
Effect of pirfenidone on renal tubulointerstitial fibrosis
Dixin LI MM , Hongbing ZENG MD , Chunyang JI MM ,
期刊论文
Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin
YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming
期刊论文
Retrospective study of the efficacy and complication of thoracoabdominal incision for nephrectomy: a comparison with flank approach
Minggen YANG, Xiaokun ZHAO
期刊论文
Intra-abdominal hypertension is an independent cause of acute renal failure after orthotopic liver transplantation
SHU Ming, PENG Chenghong, CHEN Hao, SHEN Boyong, ZHOU Guangwen, SHEN Chuan, LI Hongwei
期刊论文
Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma
期刊论文